In response to the COVID-19 pandemic, all members of the Rockefeller University clinical research enterprise came together to re-engineer processes and procedures to support exciting clinical and translational research to both better understand the nature of the infection and develop effective therapies. In this issue of the CCTS eNewsletter, articles highlight the efforts by the Research Facilitation Office, the Nursing Department, and the IRB, but every program and department participated in a heroic effort to keep the Hospital open and functioning, despite the closure of the University, during the height of the pandemic in New York City. This made it possible to arrange for the visits and blood collection from approximately 160 volunteers who recovered from COVID-19 as part of Michel Nussenzweig’s lab’s important project to isolate B lymphocyte cells making broadly neutralizing antibodies to SARS-CoV-2 for therapeutic development. Dr. Christian Gaebler, a Clinical Scholar in Dr. Nussenzweig’s lab, describes his role in the research in an article in this eNewsletter as well. The success of that project is a tribute to the dedication and bravery of the entire staff.