The Rockefeller University Center for Clinical and Translational Science (CCTS) submitted a Clinical and Translational Science Award application on September 25, 2015 to the National Center for Advancing Translational Sciences (NCATS) of the National Institutes of Health (NIH).
CCTS has been continuously funded by the Clinical and Translational Science Award (CTSA) program since the inception of the program in 2006, including a successful renewal application in 2011. The grant supports the University’s high quality translational and clinical research infrastructure that facilitates research locally, regionally and nationally and fosters innovation in research methods, training, and career development.
February 26, 2016 | Collaboration
The Rockefeller Investigators Collaborate with other New York City CTSAs and Clinical Directors Network to Build and Use the New York City Clinical Data Research Network (NYC-CDRN)
The Rockefeller University and Clinical Directors Network (CDN) are both participating in an exciting novel program to create an accessible, sustainable, scalable clinical data network that will enable patient-centered research, support a national patient-centered outcomes research network, and facilitate the development of learning healthcare systems.
The New York City Clinical Data Research Network (NYC-CDRN), funded by the Patient-Centered Outcomes Research Institute (PCORI) as part of PCORnet, is designed to link the approximately 4.4 million electronic health records (EHR) of all patients cared for at the major New York academic medical centers, and in Federally Qualified Community Health Centers affiliated with CDN to form a searchable clinical data resource.
February 26, 2016 | New Training Initiatives using Big Data
CCTS Inaugurates New Training Program on Using Big Data and Electronic Health Records to Advance Translational Research
One of the new initiatives the Rockefeller University Center for Clinical and Translational Science (CCTS) is implementing a training program to use data from electronic health records (EHRs) as a research tool to advance translational science across the entire spectrum from basic science discoveries to epidemiology. The training program will enable bench to bedside (T1) researchers to utilize EHR databases to answer basic science research questions using clinical data by analyzing large data sets to test basic and translational science hypotheses.
February 26, 2016 | Translational Opportunity
Clinical Scholar Taia Wang and Colleague Jad Maamary Discover That Anti-HA Fc Glycoforms Determines Influenza Vaccine Efficacy through Type II Fc Receptor Signaling
Studies conducted by Clinical Scholar Taia Wang, Postdoctoral Associate Jad Maamary and mentor Jeffrey V. Ravetch, which were recently published in Cell, provide exciting new information on the mechanism by which the antibody response leads to the selection of more potent antibodies over time, and open up important new translational opportunities to improve influenza vaccination. As the 2015-6 influenza season is now reaching its peak, this is welcome news!
Dr. Shen-Ying Zhang, Assistant Professor of Clinical Investigation at Rockefeller University is Co-PI with Dr. Jean-Laurent Casanova, Head of the St. Giles Laboratory of Human Genetics of Infectious Diseases, on two NIH (R01) research project grants. R01 grants are prestigious awards that provide support for health-related research and development aligned withthe mission of the NIH. Dr. Zhang is a graduate of the Clinical Scholars Program and a member of the Rockefeller Early Phase Physician Scientists (REPPS) group.
February 26, 2016 | Clinical Study Enrollment
Accrual Index, A Novel Way of Measuring the Timeliness of Clinical Study Enrollment
Investigator-initiated studies that enroll (accrue) research participants more slowly than expected delay scientific discovery. Recent studies documenting the failure of many clinical trials at the national level to accrue participants on time, or to ever reach study endpoints, led to calls for accountability in study accrual from the Institutes of Medicine and funding agencies such as NIH/NCATS/CTSA. These agencies would like to standardize the evaluation of accrual success across the CTSAs nationally, but no validated measure of this success has yet been developed.
February 26, 2016 | Meet the Scholar
Meet the Scholar: José O. Alemán, MD, PhD
Dr. José O. Alemán joined the Rockefeller University Clinical Scholars Program as an Instructor in Clinical Investigation in Dr. Jan Breslow’s Laboratory of Biochemical Genetics and Metabolism in 2013. Born and raised in Puerto Rico, Dr. Alemán completed his undergraduate studies in Chemical Engineering at Cornell University. Following a Fulbright grant in Spain, he pursued combined MD-PhD training at Harvard Medical School. During his PhD in Medical Engineering at the Massachusetts Institute of Technology, Dr. Alemán developed metabolomic and flux analysis techniques to elucidate insulin resistant metabolism in transgenic mice in collaboration with investigators at the Joslin Diabetes Center